Endocrine Abstracts

In our institution, an observed loading dose of oral colecalciferol (D3) 300 000 units is used for treatment of vitamin D deficiency (Vit D <30 nmol/l), with subsequent re-evaluation at 6 weeks and 3 months. We evaluated the follow-up of all the patients who received loading dose colecalciferol against adherence to this protocol.Method: All patients who received observed loading dose of colecalciferol for a 1-year period were included. Demographic, c...

Riedel thyroiditis is a rare chronic inflammatory disease of the thyroid. It is characterized by replacement of normal parenchyma with dense fibrotic tissue. Peripheral tissues might also be affected and this may cause airway obstruction, dysphagia, recurrent laryngeal nerve palsy and hypoparathyroidism. We report a patient with toxic adenoma previously treated with radioactive iodine and histopathologically confirmed Riedel thyroiditis.Case: A 61 years ...

Introduction: Nowadays, ultrasonography (USG) is being used very commonly and indispensably for diagnosing thyroid diseases. Heterogeneous appearance of thyroid parenchyma is associated with positivity for thyroid autoantibody and hypofunctioning of thyroid gland. On the other hand, it is not determined whether thyroid parenchyma appearing totally of normal ecogenity on USG is related to presence normal thyroid function tests or otherwise. The objective of our study was evalua...

Introduction: We submit a rare presentation of round blue cell pituitary tumour complicated by cranial diabetes insipidus following transphenoidal surgery.Case history: 47-year-old lady with severe headache was diagnosed with a 10 mm non functioning pituitary macro adenoma. Initial plan for conservative management was revised as she developed sixth cranial nerve palsy, bi temporal hemianopia and rapidly enlarging pituitary tumour to 20×18×19 mm...

Adenomyosis is an oestrogen-dependent uterine disease where ectopic, non-neoplastic endometrium is histologically observed within the myometrium. Its incidence ranges between 5 and 70% and although presenting symptoms; menorrhagia (40–50%), dysmenorrhoea (10–30%) and metrorrhagia (10–12%) are well known, its aetiopathology remains unclear. The neurotrophin, nerve growth factor (NGF), has been implicated in the aetiopathology of adenomyosis, especially in the tam...

Introduction: Accumulating evidence suggests a role for IGF1 in insulin resistance and cardiovascular disease. IGF1 enhances glucose uptake and nitric oxide (NO) production, via similar mechanisms to insulin. Previously we have reported a mouse model with global heterozygous knockout of the IGF1 receptor (IGF1RKO) that has enhanced insulin sensitivity and increased nitric oxide (NO) production in the vasculature.Methods: To investigate this further we us...

Introduction: Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It is characterized by progressive somatic disfigurement and systemic manifestations. Empty sella (ES) is an anatomical condition comprising sella turcica that is partially or completely filled with cerebrospinal fluid mainly due to intrasellar herniation of subarachnoid space. Primary ES may be associated with endocrine dysfunction ...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is associated with neoplasia and hyperfunction of the parathyroid and pituitary glands, pancreatic islet cells, and neuroendocrine cells of the gut. Many authors advocate routine subtotal or total parathyroidectomy and autotransplantation for these patients. Here we demostrate negative MEN1 and MEN4 gene mutation analysis in a case with prolactinoma and a large parathyroid adenoma that could not be localized with preope...

Aim: In this study, we aimed to evaluate ABO blood groups and Rh factor in patients with thyroid cancer. We also assessed whether the ABO/Rh factor had any effect on prognosis, agressive features and advanced stage of thyroid malignancies.Methods: Medical records of patients who underwent thyroidectomy between December 2006 and September 2014 were evaluated retrospectively. Demographical and clinical features, cytological results (according to Bethesda c...

ObjectivesAdherence to treatment is one of the most important parameters that affect the success of the treatment in hypothyroidism. We aimed to evaluate the use and adherence to treatment and determine the factors that are related to adherence in patients on levothyroxine therapy.Materials and MethodsPatients older than 18 years old and using levothyroxine for hypothyroidism were recruited. Demographical, so...